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KMID : 1007520100190030777
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Food Science and Biotechnology
2010 Volume.19 No. 3 p.777 ~ p.784
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Physicochemical Characteristics, Antimicrobial Activity, ACE Inhibitory Activity of Chitosan-salt, and Its Antihypertensive Effect
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Kim Hag-Lyeol
Park Soo-Mi
Cho Geon-Sik
Kim Kye-Yeop
Kim In-Cheol
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Abstract
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This study was performed to investigate the physicochemical characteristics after producing chitosansalt by adding chitosan to salt. Cl? value of chitosan-salt was same with that of the control group and that meant the salinity of the chitosan-salt was not different with that of the salt. While salt generally increases angiotensin converting enzyme (ACE) activity, chitosan-salt inhibited the ACE activity. For all microorganisms 3% chitosan-salt was the most effective in antimicrobial activity. When systolic blood pressure (SBP) of Sprague-dawley rats (SDR) was examined for 5 weeks to evaluate in vivo effects of chitosan-salt, all groups did not show significant difference between supplement period and group. In addition, plasma total cholesterol (TC) and triglyceride (TG) concentration were not different in all groups. This result was considered to be use of normotensive SDR so changes of SBP were investigated with spontaneous hypertensive rat (SHR). normal diet supplement group (NDSG) administered with captopril showed the largest decrease of SBP (p<0.001) and SBP of normal diet+3% chitosan salt supplement group (CSSG) also decreased significantly (p<0.001). However, that of normal+3% table salt supplement group (TSSG) increased significantly with times course (p<0.001). These results suggested that increasing blood pressure in salt intake by using chitosan was caused by not sodium but chloride and chitosan’s effect of eliminating Cl from NaCl was considered to be a main cause.
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KEYWORD
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chitosan-salt, physicochemical characteristics, antimicrobial activity, angiotensin converting enzyme (ACE) inhibitory activity, hypertension
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